TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Demonstrated that TDP-43 loss of function drives aberrant splicing events in Parkinson's disease.
james-w.-brenton
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1 min read
Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Dementia-like deficits
Demonstrated that AAV-delivered chimeric TDP-43 repressor (CTR) achieves broad brain biodistribution, restores TDP-43 splicing function, rescues neurons, and mitigates FTD-like …
Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia
TDP-43 depletion exacerbates tauopathy-dependent brain atrophy by sensitizing neurons to caspase 3-mediated tau cleavage in a multiple etiology dementia mouse model.
manoj-s.-baghel