Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

Jun 26, 2024·

Manoj S. Baghel

,

Garrett D. Burns

,

Michael Tsapatsis

,

Akarsh P. Mallika

,

André L. F. Cruz

Tianyu Cao (曹天雨)

,

et al.

· 0 min read

bioRxiv

TDP-43 Tau Multi-Proteinopathy Tauopathy

Authors

Tianyu Cao (曹天雨) (he/him)

Postdoctoral Fellow

Postdoctoral Fellow at Johns Hopkins School of Medicine studying TDP-43 loss of function and developing splicing-based therapies for ALS and frontotemporal dementia.

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Validation of TDP-43 Splicing Repression as a Therapeutic Strategy for ALS and FTD Apr 1, 2024 →