曹天雨 Tianyu Cao

博客开张

Sat, 06 Jun 2026 00:00:00 +0000

欢迎来到我的中文博客。后续会陆续更新科研笔记、AI 项目记录和帆船相关内容。

TDP-43 loss of function drives aberrant splicing in Parkinson's disease

Thu, 04 Sep 2025 00:00:00 +0000

JuncForge

Sun, 01 Jun 2025 00:00:00 +0000

简介

JuncForge 是一个计算流程，用于设计跨越隐秘外显子（CE）剪接连接处的 qPCR 引物对，适用于 RNA 剪接研究，包括 TDP-43 功能缺失与神经退行性疾病中隐秘外显子纳入等相关课题。

主要功能

给定标注了内含子中隐秘外显子的 GenBank 文件，流程将：

定位 CE 特征及其左右连接处
通过 Primer3 设计满足连接处跨越约束的引物对
对基因组与 RefSeq mRNA 进行 pair-wise BLAST 筛选
保留预期仅扩增含 CE 转录本的引物

技术栈

Python、Primer3、BLAST

链接

GitHub:

Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Dementia-like deficits

Wed, 01 Jan 2025 00:00:00 +0000

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

Wed, 26 Jun 2024 00:00:00 +0000

Validation of TDP-43 Splicing Repression as a Therapeutic Strategy for ALS and FTD

Mon, 01 Apr 2024 00:00:00 +0000

The association between retina thinning and hippocampal atrophy in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review

Sat, 01 Jul 2023 00:00:00 +0000

Safety and efficacy of edaravone in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis

Sun, 01 Jan 2023 00:00:00 +0000

Thoughts on Digital Inheritance of Experiences of Famous and Veteran Physicians of Traditional Chinese Medicine

Sun, 01 Jan 2023 00:00:00 +0000

肌萎缩侧索硬化中医证候要素的Meta分析

Sun, 01 Jan 2023 00:00:00 +0000

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Thu, 01 Dec 2022 00:00:00 +0000

Meta analysis of efficacy and safety of traditional Chinese medicine combined with hydroxychloroquine sulfate in the treatment of Sjogren's syndrome

Sat, 01 Jan 2022 00:00:00 +0000

The Correlation Between Olfactory Test and Hippocampal Volume in Alzheimer's Disease and Mild Cognitive Impairment Patients: A Meta-Analysis

Wed, 01 Dec 2021 00:00:00 +0000

柴胡类方对比选择性五羟色胺再摄取抑制剂治疗肿瘤相关抑郁Meta分析

Fri, 01 Jan 2021 00:00:00 +0000

活血化瘀法联合常规疗法治疗脑心综合征的Meta分析

Fri, 01 Jan 2021 00:00:00 +0000

Evaluation of the efficacy and safety of the use of acupuncture for the adjuvant treatment of patients with post-stroke cognitive impairment: protocol for a randomized controlled trial

Sat, 01 Aug 2020 00:00:00 +0000

基于数据挖掘的针刺治疗血管性认知损害选穴组方规律研究

Sat, 01 Aug 2020 00:00:00 +0000

基于数据挖掘探讨古籍中药治疗肌萎缩侧索硬化相关痿证的处方用药规律

Mon, 01 Jun 2020 00:00:00 +0000

丁苯酞软胶囊治疗血管性痴呆疗效和安全性的Meta分析

Wed, 01 Apr 2020 00:00:00 +0000

丁苯酞软胶囊治疗阿尔茨海默病的有效性和安全性的Meta分析

Sun, 01 Dec 2019 00:00:00 +0000