TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Demonstrated that TDP-43 loss of function drives aberrant splicing events in Parkinson's disease.
james-w.-brenton
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Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Dementia-like deficits
Demonstrated that AAV-delivered chimeric TDP-43 repressor (CTR) achieves broad brain biodistribution, restores TDP-43 splicing function, rescues neurons, and mitigates FTD-like …
Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia
TDP-43 depletion exacerbates tauopathy-dependent brain atrophy by sensitizing neurons to caspase 3-mediated tau cleavage in a multiple etiology dementia mouse model.
manoj-s.-baghel
Validation of TDP-43 Splicing Repression as a Therapeutic Strategy for ALS and FTD
Conference abstract presented at ASGCT 2024 on validating TDP-43 splicing repression as a therapeutic strategy for ALS and FTD.
The association between retina thinning and hippocampal atrophy in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review
Meta-analysis and systematic review examining the association between retina thinning and hippocampal atrophy in Alzheimer's disease and MCI.
shaoyi-chen
肌萎缩侧索硬化中医证候要素的Meta分析
Meta-analysis of TCM syndrome elements in amyotrophic lateral sclerosis.
yijia-teng
Thoughts on Digital Inheritance of Experiences of Famous and Veteran Physicians of Traditional Chinese Medicine
Discussion on digital approaches for preserving and inheriting the clinical experiences of renowned TCM practitioners.
jingnian-ni
Safety and efficacy of edaravone in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis
Systematic review and meta-analysis evaluating the safety and efficacy of edaravone in ALS patients.
meng-gao
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Identified novel disease stage-specific microglia subtypes induced by synergistic Aβ and tau pathologies.
dong-won-kim
Meta analysis of efficacy and safety of traditional Chinese medicine combined with hydroxychloroquine sulfate in the treatment of Sjogren's syndrome
Meta-analysis of TCM combined with hydroxychloroquine sulfate for Sjogren's syndrome treatment.
suxian-huang